Innate Immunity vs. Antibody Response
Updated: May 8, 2021
Every day we are alive, humans encounter potentially harmful disease causing organisms, or “pathogens”, like bacteria or viruses. Yet most of us are still able to function properly and live life without constantly being sick. That’s because the human body requires a multilayered immune system to keep it running smoothly. The two main classes of the immune system are the innate immune system and the adaptive immune system, or “acquired immunity”.
Innate Immune System:
A single bacterium with a doubling time of one hour can produce almost 20 million progeny, a full-blown infection, in a single day. Therefore, during the first critical hours and days of exposure to a new pathogen, we rely on our innate immune system to protect us from infection. Innate immune responses are not specific to a particular pathogen in the way that the adaptive immune responses are. They depend on a group of proteins and phagocytic cells that recognize conserved features of pathogens and become quickly activated to help destroy invaders.
The innate immune system is made of defenses against infection that can be activated immediately once a pathogen attacks. The innate immune system is essentially made up of barriers that aim to keep viruses, bacteria, parasites, and other foreign particles out of your body or limit their ability to spread and move throughout the body. The innate immune system includes:
such as skin, the gastrointestinal tract, the respiratory tract, the nasopharynx, cilia, eyelashes and other body hair.
such as secretions, mucous, bile, gastric acid, saliva, tears, and sweat.
General Immune Responses
such as inflammation, complement, and non-specific cellular responses. The inflammatory response actively brings immune cells to the site of an infection by increasing blood flow to the area. Complement is an immune response that marks pathogens for destruction and makes holes in the cell membrane of the pathogen.
Two of many major cells working with the Innate Immune System are Macrophages and Natural Killer (NK) cells...
Macrophages: Macrophages, commonly abbreviated as “Mφ”, are efficient phagocytic cells that can leave the circulatory system by moving across the walls of capillary vessels. The ability to roam outside of the circulatory system is important, because it allows macrophages to hunt pathogens with less limits. Macrophages can also release cytokines in order to signal and recruit other cells to an area with pathogens.
Natural Killer cells: Natural Killer cells (NK cells), do not attack pathogens directly. Instead, natural killer cells destroy infected host cells in order to stop the spread of an infection. Infected or compromised host cells can signal natural kill cells for destruction through the expression of specific receptors and antigen presentation.
Adaptive Immune System:
The adaptive immune system, also called acquired immunity, uses specific antigens to strategically mount an immune response. Unlike the innate immune system, which attacks only based on the identification of general threats, the adaptive immunity is activated by exposure to pathogens, and uses an immunological memory to learn about the threat and enhance the immune response accordingly. The adaptive immune response is much slower to respond to threats and infections than the innate immune response, which is primed and ready to fight at all times.
Unlike the innate immune system, the adaptive immune system relies on fewer types of cells to carry out its tasks: B cells and T cells.
B cells also express a specialized receptor, called the B cell receptor (BCR). B cell receptors assist with antigen binding, as well as internalization and processing of the antigen. B cell receptors also play an important role in signaling pathways. After the antigen is internalized and processed, the B cell can initiate signaling pathways, such as cytokine release, 7 to communicate with other cells of the immune system.
Unlike antibodies, which can bind to antigens directly, T cell receptors can only recognize antigens that are bound to certain receptor molecules, called Major Histocompatibility Complex class 1 (MHCI) and class 2 (MHCII).
Because the adaptive immune system can learn and remember specific pathogens, it can provide long-lasting defense and protection against recurrent infections. When the adaptive immune system is exposed to a new threat, the specifics of the antigen are memorized so we are prevented from getting the disease again. The concept of immune memory is due to the body’s ability to make antibodies against different pathogens.
A good example of immunological memory is shown in vaccinations. A vaccination against a virus can be made using either active, but weakened or attenuated virus, or using specific parts of the virus that are not active. Both attenuated whole virus and virus particles cannot actually cause an active infection. Instead, they mimic the presence of an active virus in order to cause an immune response, even though there are no real threats present. By getting a vaccination, you are exposing your body to the antigen required to produce antibodies specific to that virus, and acquire a memory of the virus, without experiencing illness. This, in my opinion, may be specific to the exact virus but viruses, like this most recent one, are mutating thousands of times. What happens as it mutates? Will it help or hinder the immunity of the host? And there may be another problem with attenuated vaccines.
Some breakdowns in the immunological memory system can lead to autoimmune diseases. Molecular mimicry of a self‐antigen by an infectious pathogen, such as bacteria and viruses, may trigger autoimmune disease due to a cross-reactive immune response against the infection. Examples of an organism that uses molecular mimicry to hide from immunological defenses is Streptococcus infection or Yersinia Enterocolitica.
In addition, one type of immune enhancement is known as Antibody Dependent Enhancement (ADE). This is a process where a virus leverages antibodies to aid infection. In short, the antibodies stimulated by a vaccine amplify the infection rather than prevent its damage. This should concern anyone looking to build a strong immune system.
Therefore, we should be looking to build our God given innate immune system (true immune response) as a general killer to all unwanted pathogens. The adaptive immune system falls mostly on our vaccination program (antibody response) which has led us to more histamine, allergies, cytokine storms in our bodies, autoimmune disorders, and other unknown factors that may take years to discover the damage. Don't take my word for it..
Please see the link below from an award winning researcher - Dr. Sucharit Bhakdi. In addition, please see the additional video on my home page named Vaccine Disaster Ahead. This is an interview (with excellent analysis/commentary by Del Bigtree) on March 6, 2021 with one of the leading vaccine experts, Geert Vanden Bossche. He has worked with many top vaccine companies for worldwide distribution, including Senior Developer for the Bill and Melinda Gates Foundation. If you are concerned because you have received any of the Coronavirus vaccines or if you just want more information on keeping a strong innate immune system, please contact us. Knowledge is power, Love over fear, God over deceit 😊